DEVELOPMENT AND ASSESSMENT OF A POINT-OF-CARE APPLICATION (GENOMIC MEDICINE GUIDANCE) FOR HERITABLE THORACIC AORTIC DISEASE

Development and Assessment of a Point-of-Care Application (Genomic Medicine Guidance) for Heritable Thoracic Aortic Disease

Abstract BackgroundGenetic testing can determine familial and personal risks for heritable thoracic aortic aneurysms and dissections (TAD).The 2022 American College of Cardiology/American Heart Association guidelines for TAD recommend management decisions based on the specific gene mutation.However, many clinicians lack sufficient comfort or insigh

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The Origin and Evolution of Baeyer-Villiger Monooxygenases (BVMOs): An Ancestral Family of Flavin Monooxygenases.

The Baeyer-Villiger Monooxygenases (BVMOs) are enzymes belonging to Comforter Set the "Class B" of flavin monooxygenases and are capable of performing exquisite selective oxidations.These enzymes have been studied from a biotechnological perspective, but their physiological substrates and functional roles are widely unknown.Here, we investigated th

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N6-methyladenosine modification of HIV-1 RNA suppresses type-I interferon induction in differentiated monocytic cells and primary macrophages.

N6-methyladenosine (m6A) is a prevalent RNA modification that plays a key role in regulating eukaryotic cellular mRNA functions.RNA m6A modification is regulated by two groups of cellular proteins, writers and erasers that add or remove m6A, respectively.HIV-1 RNA contains m6A modifications that Avocado modulate viral infection and gene expression

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The modification and evaluation of an ELISA test for the surveillance of Mycobacterium avium subsp. paratuberculosis infection in wild ruminants

Abstract Background Enzyme-linked immunosorbent assay (ELISA) is often used to test wildlife samples for Mycobacterium avium subsp.paratuberculosis (MAP) infection.However, commercially available kits are only validated for use with domestic ruminant species.A literature review was performed to document the current use of MAP serum ELISA in wild an

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